What this test shows
This test shows whether we have deficiencies in amino acids, or lack the necessary vitamins and minerals which are required for methylation. Methylation is a complex process of biochemical reactions, which underpins so many processes in the body. It involves the donation and transfer of methyl groups to different molecules, which changes their structure and function. These methyl groups essentially act like switches, turning genes on and off, and driving many processes in the body including energy production, hormone regulation, neutralisation and detoxification of hormones and toxins, cell regeneration and repair, fat metabolism, synthesis of neurotransmitters (which regulate mood and impact on mental health), immune function, heart/vascular health and much more.
A wide range of nutrients (vitamins, minerals and amino acids), are essential for optimising methylation. But gene variations(SNPs) and oxidative stressors can also affect methylation.
SNPs can be identified as additional markers to this test – see the Methylation Genomics Test – 3534 below, at an additional cost of £130.
Oxidative stress can also be tested as a stand alone test ie can be ordered independently of the Methylation Test– click here for the Oxidative Stress 2 Test (MET05)
Who this test is for
Methylation defects have been associated with many clinical conditions including, but not limited to cancer, autism, ADHD, congenital and neural tube defects, cognitive decline, depression, cardiovascular disease, and schizophrenia.
The test may be helpful to patients with detoxification concerns, including those who take hormone therapy, drink alcohol or who are exposed to toxins; with chronic fatigue; with Parkinson’s and cognitive decline (neurological disorders); who experience mood disorders, anxiety, depression, bipolar and schizophrenia; who may be at risk of cancer; with atherosclerosis, coronary artery disease, high blood pressure. This list is not exhaustive – the symptoms arising from methylation defects is wide ranging since it is a process which underpins most systems in the body.
Sample type: Blood – you will need to arrange to attend one of our phlebotomy clinics to get a blood draw; click here to find your nearest clinic, surgery or hospital offering this service.
Turnaround time: 20 days
Before taking this test: If the patient is supplementing with SAM-e or amino acid formulations, these may affect test results.
The Methylation Genomics Test (3534) identifies whether a genetic variation may be impacting on your methylation ability, and tests for variations (SNPs) in 9 genes which can alter enzyme activity and impair methylation. The Methylation Genomics Test (3534) can only be purchased as an add-on to the Methylation Test (3534), at an additional price of £130. A separate sample (buccal swab) is required for each of the 9 SNPs tested, as follows:
BHMT – protective effects associated with birth defects and breast cancer
COMT – implicated in mood disorders (panic disorder, anxiety, aggressiveness, anger), eating disorders, severity of bi-polar disorder, fibromyalgia, migraines, breast cancer risk
CBS – reduced risk of lymphoma, coronary artery disease, venous disease and deep vein thrombosis
GNMT – associated with liver detoxification and prostrate cancer pathways
MAT1A – associated with cardiovascular (stroke) risk
MTR – associated with congenital birth defects including spina bifida, cleft lip/palette, cardiac defects
MTRR – associated with cancers, birth defects, metabolic syndrome and mood disorders
MTHFR (C677T and A1298C) – associated with cancers, diabetes, depression, Parkinsons, psoriasis, risk of birth defects and Down’s Syndrome, infertility and cardiovascular disease.
SHMT – associated with cancer
Please contact us for further information and to obtain full test criteria.
Please refer to the section Genetic Tests for the full range of SNPs and genetic tests available.